Aston Martin, which has its headquarters in Gaydon, Warwickshire, employs about 3,000 people, meaning job losses will total around 600.
Deborah Alsina, chief executive of Arthritis UK, said: "This is a crushing blow for those individuals who have finally made it to the front of the orthopaedic surgery queue after a long time waiting.
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Federica Mercuriello built her business in the “in-between moments.”